pentobarbital will minimize the extent or outcome of pitolisant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Pitolisant exposure is lowered by 50% if coadministered with strong CYP3A4 inducers.pentobarbital will lower the extent or outcome of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 m… Read More